2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W011051S2
    2-Arachidonoylglycerol-d11
    2-Arachidonoylglycerol-d11 is deuterium labeled 2-Arachidonoylglycerol.2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system[1].
    2-Arachidonoylglycerol-d<sub>11</sub>
  • HY-163394
    CB2 receptor agonist 6
    		Agonist
    CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease.
    CB2 receptor agonist 6
  • HY-152253
    CB2R/FAAH modulator-2
    		Agonist
    CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
    CB2R/FAAH modulator-2
  • HY-113204R
    N-Oleoyl glycine (Standard)
    		Activator
    Diludine (Standard) is the analytical standard of Diludine. This product is intended for research and analytical applications. Diludine has antioxidant properties, targeting oxidative stress-related pathways. By improving antioxidative status and reducing β-hydroxybutyrate levels, Diludine alleviates oxidative stress during the parturition period in dairy cows. It is primarily used during the transition period in dairy cows to increase milk yield and milk fat content, as well as to improve health during parturition.
    N-Oleoyl glycine (Standard)
  • HY-110016
    Docosatetraenylethanolamide
    		Agonist
    Docosatetraenylethanolamide (DEA) is a cannabinoid receptor 1 (CB1) agonist. Docosatetraenylethanolamide inhibits the specific binding of cannabinoid probe to rat synaptosomal membranes with a Ki value of 34.4 nM. Docosatetraenylethanolamide can be used in the research of nervous system.
    Docosatetraenylethanolamide
  • HY-162083
    CB2R/5-HT1AR agonist 1
    		Agonist
    CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB2 receptor (EC50=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT1A receptor (EC50=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties.
    CB2R/5-HT1AR agonist 1
  • HY-152576
    CB2R agonist 1
    		Agonist
    CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role.
    CB2R agonist 1
  • HY-123594
    R-2 Methanandamide
    		Agonist
    R-2 Methanandamide (Compound 2) is a cannabinoid Anandamide (HY-10863) analog with a Ki of 119 nM for the cannabinoid receptor (Ki is determined using rat brain membranes with PMSF).
    R-2 Methanandamide
  • HY-122960
    Epifriedelanol acetate
    Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb.
    Epifriedelanol acetate
  • HY-106010
    LBP1
    		Agonist
    LBP1 is an orally active and low brain penetrant CB1 receptor agonist. LBP1 exhibits significant anti-allodynic and anti-hyperalgesic effects in rodent models of neuropathic pain.
    LBP1
  • HY-119352
    S-2 Methanandamide
    		Agonist
    S-2 Methanandamide is a potent CB1 receptor agonist, with IC50 values of 173 nM (with PMSF) and 8216 nM for CB1 and CB2, respectively.
    S-2 Methanandamide
  • HY-162908
    TRPV1/CB2 agonist 1
    		Agonist
    TRPV1/CB2 agonist 1 (compound 41) is a TRPV1/CB2 agonist, with an EC50 of 26.8 μM for hTRPV1. TRPV1/CB2 agonist 1 can be used in nervous system related research.
    TRPV1/CB2 agonist 1
  • HY-103330
    TC-C 14G
    		Inhibitor
    TC-C 14G (Compd 14g) is a Cannabinoid-1 Receptor (CB1R) inverse agonist, with a Ki of 4 nM and EC50 of 11 nM for HCB1R, respectively.
    TC-C 14G
  • HY-163825
    RNB-61
    		Agonist
    RNB-61 is an oral active agonist of cannabinoid CB2 receptor (CB2R), with the Ki ranging from 0.13 nM to 1.81 nM. RNB-61 has nephroprotective and/or antifibrotic effects. RNB-61 has negligible penetration into the brain.
    RNB-61
  • HY-N6097
    Amauromine
    		Antagonist
    Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with Ki and Kb values of 178 nM and 66.6 nM, respectively.
    Amauromine
  • HY-12244
    BB-22
    		Ligand
    BB-22 is a cannabinoid wih dopamine (DA) stimulant properties. BB-22 shows affinity to CB1 receptors with a Ki value of 0.11 nM and an EC50 value of 2.9 nM.
    BB-22
  • HY-150067
    CB1R antagonist 1
    		Agonist 99.89%
    CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity.
    CB1R antagonist 1
  • HY-125407
    Palmitoyl serinol
    Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin.
    Palmitoyl serinol
  • HY-12095
    CB1 inverse agonist 2
    		Agonist
    CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model.
    CB1 inverse agonist 2
  • HY-150030
    CB1/2 agonist 4
    		Agonist
    CB1/2 agonist 4 is a full CB1 agonist and CB2 partial agonist with EC50 values of 15.09 nM and 1.16 nM, respectively. CB1/2 agonist 4 also has hCB1 and hCB2 receptor affinities with Ki values of 1.1 nM and 4.2 nM, respectively. CB1/2 agonist 4 has a significant antinociceptive activity, and also can activate cannabinoid and TRPV1 receptor with values of IC50 and EC50 is 0.8 μM and 0.12 μM, respectively.
    CB1/2 agonist 4
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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